2023

Mach P, Giorgetti L. Integrative approaches to study enhancer–promoter communication. Current Opinion in Genetics & Development Vol. 80, 102052 (2023)

2022

Zuin J, Roth G, Zhan Y, Cramard J, Redolfi J, Piskadlo E, Mach P, Kryzhanovska M, Tihanyi G, Kohler H, Eder M, Leemans C, van Steensel B, Meister P, Smallwood S & Giorgetti L, Nonlinear control of transcription through enhancer–promoter interactions. Nature 604, 571–577 (2022)

Mach P, Kos PI, Zhan Y, Cramard J, Gaudin S, Tünnermann J, Marchi E, Eglinger J, Zuin J, Kryzhanovska M, Smallwood S, Gelman L, Roth G, Nora EP, Tiana G, Giorgetti L. Cohesin and CTCF control the dynamics of chromosome folding. Nature Genetics, 54(12), 1907-1918 (2022)

2021

Eichenberger BT, Zhan Y, Rempfler M, Giorgetti L, Chao J. deepBlink: threshold-independent detection and localization of diffraction-limited spots. Nucleic Acids Research 49, 7292–7297 (2021)

Zuin J, Roth G, Zhan Y, Cramard J, Redolfi J, Piskadlo E, Mach P, Kryzhanovska M, Tihanyi G, Kohler H, Meister P, Smallwood S, Giorgetti L. Nonlinear control of transcription through enhancer-promoter interactions. bioRxiv (2021)

2020

McCord RP, Kaplan N, Giorgetti L. Chromosome Conformation Capture and Beyond: Toward an Integrative View of Chromosome Structure and Function. Molecular Cell 77, 688-708 (2020)

Galupa R, Nora EP, Worsley-Hunt R, Picard C, Gard C, van Bemmel JG, Servant N, Zhan Y, El Marjou F, Johanneau C, Diabangouaya P, Le Saux A, Lameiras S, Pipoli da Fonseca J, Loos F, Gribnau J, Baulande S, Ohler U, Giorgetti L, Heard E. A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary. Molecular Cell 77: 352-367 (2020)

2019

van Bemmel JG, Galupa R, Gard C, Servant N, Picard C, Davies J, Szempruch AJ, Zhan Y, Żylicz JJ, Nora EP, Lameiras S, de Wit E, Gentien D, Baulande S, Giorgetti L, Guttman M, Hughes JR, Higgs DR, Gribnau J, Heard E. The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist. Nature Genetics 51: 1024-1034 (2019)

Redolfi J*, Zhan Y*, Valdes-Quezada C*, Kryzhanovska M, Guerreiro I, Iesmantavicius V, Pollex T, Grand RS, Mulugeta E, Kind J, Tiana G, Smallwood SA, de Laat W, Giorgetti L. DamC reveals principles of chromatin folding in vivo without crosslinking and ligation. Nature Structural & Molecular Biology 26, 471-480 (2019)

Mutzel V, Okamoto I, Dunkel I, Saitou M, Giorgetti L, Heard E, Schulz EG. A symmetric toggle switch explains the onset of random X inactivation in different mammals. Nature Structure & Molecular Biology 26: 350-360 (2019)

2018

Marti-Renom M, Almouzni G,Bickmore W, Bystricky K, Cavalli G, Fraser P, Gasser SM, Giorgetti L, Heard E, Nicodemi M, Nollmann M, Orozco M, Pombo A, Torres-Padilla ME. Challenges and guidelines toward 4D nucleome data and model standards. Nature Genetics 50, 1352-1358 (2018)

Tiana G, Giorgetti L. Integrating experiment, theory and simulation to determine the structure and dynamics of mammalian chromosomes. Current Opinion in Structural Biology 49:11-17 (2018)

2017

Horvathova I, Voigt F, Kotrys AV, Zhan Y, Artus-Revel CG, Eglinger J, Stadler MB, Giorgetti L, Chao JA. The Dynamics of mRNA Turnover Revealed by Single-Molecule Imaging in Single Cells. Molecular Cell 68: 615-625 (2017)

Zhan Y, Mariani L, Barozzi I, Schulz EG, Bluthgen N, Stadler M, Tiana G, Giorgetti L. Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes. Genome Research  27: 479-490 (2017)

2016

Giorgetti L, Heard E. Closing the loop: 3C versus DNA FISH. Genome Biology 17:215 (2016)

Zhan Y, Giorgetti L, Tiana G. Looping probability of random heteropolymers helps to understand the scaling properties of biopolymers. Physical Review E 94:032402 (2016)

Giorgetti L, Lajoie BR, Carter AC, Attia M, Zhan Y, Xu J, Chen CJ, Kaplan N, Chang HY, Heard E, Dekker J. Structural organization of the inactive X chromosome in the mouse. Nature 535:575-57 (2016)

Tiana G, Amitai A, Pollex T, Piolot T, Holcman D, Heard E, Giorgetti L. Structural fluctuations of the chromatin fiber within topologically associating domains. Biophysical Journal 110:1234-1245 (2016)

2015

Giorgetti L, Piolot T, Heard E. High-resolution 3D DNA FISH Using Plasmid Probes and Computational Correction of Optical Aberrations to Study Chromatin Structure at the Sub-Megabase Scale. Methods in Molecular Biology 1262:37-53 (2015)

selected publications before 2015

Giorgetti L, Galupa R, Nora EP, Piolot T, Lam F, Dekker J, Tiana G, Heard E. Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription. Cell 157:950-63 (2014)

Nora EP, Lajoye B, Schulz E, Giorgetti L, Okamoto I, Servant N, Piolot T, van Berkum NL, Meisig J, Sedat J, Gribnau J, Barillot E, Blüthgen N, Dekker J, Heard E. Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature 485:381-5 (2012)

Giorgetti L, Siggers T, Tiana G, Caprara G, Notarbartolo S, Corona T, Pasparakis M, Milani P, Bulyk ML, Natoli G. Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs. Molecular Cell 37:418-28 (2010)

For a full list of publications, please see here.